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M94A3082.TXT
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1994-10-25
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Document 3082
DOCN M94A3082
TI Evaluation of immuno-status in HIV disease using serum
2'5'-oligoadenylate synthetase activity.
DT 9412
AU Ueda M; Higasa S; Suehiro A; Kakishita E; 2nd Dept. of Internal
Medicine, Hyogo College of Medicine, Japan.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):158 (abstract no. PB0060). Unique
Identifier : AIDSLINE ICA10/94369493
AB OBJECTIVE: 2'5'-oligoadenylate synthetase (2-5AS) has been reported to
be induced by interferons (IFN) and its activity in mononuclear cells
reliably reflects activation of the IFN system by viral infections. To
evaluated the immuno-status in HIV disease and the progression of the
disease, serum 2-5AS activities in hemophiliacs were measured. METHODS:
Serum 2-5AS activities in 28 hemophiliacs, fifteen HIV seropositive and
thirteen HIV seronegative patients. The correlations between serum 2-5AS
activity and the other conventional Aparameters for the evaluation of
immunostatus were also examined. RESULTS: Serum 2-5AS activity in HIV
seropositive hemophiliacs was significantly higher than in HIV
seronegative hemophiliacs. In HIV seropositive hemophiliacs, serum 2-5AS
activities were negatively correlated with CD4+ lymphocytes and
CD4+/CD8+ ratio. DISCUSSION AND CONCLUSIONS: Our results showed that
serum 2-5AS activity was elevated by HIV infection and might be useful
marker to evaluate the immuno-status in HIV disease. Further study
confirm the correlation between 2-5AS activity and clinical stage of HIV
suggested to be needed.
DE CD4-CD8 Ratio Hemophilia/IMMUNOLOGY Human HIV
Infections/CLASSIFICATION/*IMMUNOLOGY HIV Seronegativity/IMMUNOLOGY
HIV Seropositivity/CLASSIFICATION/*IMMUNOLOGY Leukocyte Count
Prognosis Reference Values T4 Lymphocytes/IMMUNOLOGY
2',5'-Oligoadenylate Synthetase/*BLOOD MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).